Blockade of connexin43-containing hemichannel attenuates the LPS-induced inflammatory response in human dental pulp cells by inhibiting the extracellular flux of ATP and HMGB1
Peiling Hu, Ping Long, Ruotong Li, Xiaorong Lan, Yuanpei He, Guangwen Li, Shiting Li · 2024
Read Blockade of connexin43-containing hemichannel attenuates the LPS-induced inflammatory response in human dental pulp cells by inhibiting the extracellular flux of ATP and HMGB1 by Peiling Hu, Ping Long, Ruotong Li, Xiaorong Lan, Yuanpei He, Guangwen Li, Shiting Li (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11646852.txt.
Description
Peiling Hu and co-authors study in 2024 how blocking a channel protein calms inflammation in human tooth pulp cells. Too much inflammation after an infection is cleared can block the pulp's repair, so control matters in deep decay. The channel lets small molecules pass between and out of cells, steering both inflammation and repair.
A bacterial toxin was used to inflame the pulp cells in the lab. Blocking the channel form cut the cells' release of two alarm molecules that drive swelling and pain. The team first charted where the channel appears in infected human molars. A drug that plugs this channel might help dentists save teeth that now need root work. The study ties the channel to known danger signals.
Catalog record
| CREATOR | Peiling Hu, Ping Long, Ruotong Li, Xiaorong Lan, Yuanpei He, Guangwen Li, Shiting Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |