Efficacy and Safety of a Tetravalent Dengue Vaccine (TAK-003) in Children With Prior Japanese Encephalitis or Yellow Fever Vaccination
Chukiat Sirivichayakul, Shibadas Biswal, Xavier Saez-Llorens, Eduardo López-Medina, Charissa Borja-Tabora, Lulu Bravo, Pope Kosalaraksa, Maria Theresa Alera, Humberto Reynales, Luis Rivera, Veerachai Watanaveeradej, Delia Yu, Felix Espinoza, Reynaldo Dietze, LakKumar Fernando, V Pujitha Wickramasing · 2024
Read Efficacy and Safety of a Tetravalent Dengue Vaccine (TAK-003) in Children With Prior Japanese Encephalitis or Yellow Fever Vaccination by Chukiat Sirivichayakul, Shibadas Biswal, Xavier Saez-Llorens, Eduardo López-Medina, Charissa Borja-Tabora, Lulu Bravo, Pope Kosalaraksa, Maria Theresa Alera, Humberto Reynales, Luis Rivera, Veerachai Watanaveeradej, Delia Yu, Felix Espinoza, Reynaldo Dietze, LakKumar Fernando, V Pujitha Wickramasing (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11646590.txt.
Description
Chukiat Sirivichayakul and co-authors ask whether past shots against two related viruses change how well a dengue vaccine works in children, in a 2024 study. Dengue, yellow fever, and Japanese encephalitis all belong to one virus family, so prior immunity might help or hinder a new vaccine. The trial gave the dengue vaccine TAK-003 or a placebo to over 20,000 children aged 4 to 16.
About 21 percent of the children had a yellow fever shot before, and about 24 percent had a Japanese encephalitis shot. After 57 months, vaccine protection measured 56 percent in the yellow fever group, 78 percent in the other group, and 54 percent in children with neither shot. The team trace much of that gap to which dengue types circulated locally, not to the prior shots. Serious side effects were alike across groups, so prior shots seem not to change the vaccine's value.
Catalog record
| CREATOR | Chukiat Sirivichayakul, Shibadas Biswal, Xavier Saez-Llorens, Eduardo López-Medina, Charissa Borja-Tabora, Lulu Bravo, Pope Kosalaraksa, Maria Theresa Alera, Humberto Reynales, Luis Rivera, Veerachai Watanaveeradej, Delia Yu, Felix Espinoza, Reynaldo Dietze, LakKumar Fernando, V Pujitha Wickramasing |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |