Improved Antitumor Efficiency of N4-Tetradecyloxycarbonyl Gemcitabine-Loaded Liposomes for Pancreatic Cancer Chemotherapy
Dan Wang, Xiaobo Wang, Yan Li, Xiaowei Wang, Xuelei Wang, Jiayi Su, Apeng Wang, Kai Lv, Mingliang Liu, Guimin Xia · 2024
Read Improved Antitumor Efficiency of N4-Tetradecyloxycarbonyl Gemcitabine-Loaded Liposomes for Pancreatic Cancer Chemotherapy by Dan Wang, Xiaobo Wang, Yan Li, Xiaowei Wang, Xuelei Wang, Jiayi Su, Apeng Wang, Kai Lv, Mingliang Liu, Guimin Xia (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11646436.txt.
Description
Dan Wang and co-authors wrap a fat-loving version of a standard chemotherapy drug in liposomes against pancreatic cancer in a 2024 study. Gemcitabine works but vanishes from blood fast and brings side effects. A greasy derivative tucked into fat bubbles might linger and concentrate in tumors.
The bubbles formed evenly, loaded nearly all their cargo, and entered cells about a hundred times better than the plain drug. Cancer cells died at lower doses, moved less, and the cargo freed inside cell recycling compartments. In mice, tumors shrank seventy to ninety percent depending on the model, spread was curbed, and survival lengthened without visible toxicity. Blood levels lasted far longer.
Catalog record
| CREATOR | Dan Wang, Xiaobo Wang, Yan Li, Xiaowei Wang, Xuelei Wang, Jiayi Su, Apeng Wang, Kai Lv, Mingliang Liu, Guimin Xia |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |