Exploring the Role of SMPD3 in the lncRNA-miRNA-mRNA Regulatory Network in TBI Progression by Influencing Energy Metabolism
Changmeng Cui, Biao Xu, Hui Liu, Changshui Wang, Tao Zhang, Pei Jiang, Lei Feng · 2024
Read Exploring the Role of SMPD3 in the lncRNA-miRNA-mRNA Regulatory Network in TBI Progression by Influencing Energy Metabolism by Changmeng Cui, Biao Xu, Hui Liu, Changshui Wang, Tao Zhang, Pei Jiang, Lei Feng (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11646434.txt.
Description
Changmeng Cui and six co-authors hunt the gene wiring that links brain injury to energy failure. Traumatic brain injury disturbs the brain's fuel use, and long RNA networks may steer that slide. The team mined three public gene datasets for changed genes, then threaded long non-coding RNAs, microRNAs, and messenger RNAs into one regulatory web. Energy-related genes from a signature database narrowed the field.
One gene, SMPD3, stood out as the hub, tied to a microRNA partner and to moderate unconsciousness and female patients in the data. Protein partners pointed at cell death and fat metabolism. In injured mouse brains, SMPD3 and two partners ran low.
Catalog record
| CREATOR | Changmeng Cui, Biao Xu, Hui Liu, Changshui Wang, Tao Zhang, Pei Jiang, Lei Feng |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |