Compound Probiotics Improve Neuropathic Pain Prognosis in a Murine Model of Chronic Constriction Injury
Xiaomei Wang, Yinsheng Chen, Shuwen Qian, Jia Kong, Zehua Su, Qingxiu Wang, Lijun Liao · 2024
Read Compound Probiotics Improve Neuropathic Pain Prognosis in a Murine Model of Chronic Constriction Injury by Xiaomei Wang, Yinsheng Chen, Shuwen Qian, Jia Kong, Zehua Su, Qingxiu Wang, Lijun Liao (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11646395.txt.
Description
Xiaomei Wang and co-authors test probiotics against nerve pain in mice in a 2024 study. Nerve pain after injury links to a disturbed gut flora. Thirty mice were split into three groups: sham surgery, nerve constriction injury, and the same injury plus daily probiotics by mouth. Pain was gauged by touch and heat response tests, alongside walking prints.
Four weeks on, treated mice tolerated touch and heat far better than untreated injured mice. Their gait improved, and the calf muscle on the injured side wasted less. Gut scans showed the injury had raised microbial diversity and shifted key groups. Probiotics pulled those shifts back toward normal, restoring one helpful genus and trimming another. The authors conclude that compound probiotics eased pain and muscle loss in this model. They tie the benefit to rebalanced gut microbes.
Catalog record
| CREATOR | Xiaomei Wang, Yinsheng Chen, Shuwen Qian, Jia Kong, Zehua Su, Qingxiu Wang, Lijun Liao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |