Genomic Epidemiology of Clostridioides difficile ST81 in Multiple Hospitals in China
Xufen Xia, Tao Lv, Lisi Zheng, Yuhong Zhao, Ping Shen, Danhua Zhu, Yunbo Chen · 2024
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Description
Xufen Xia and co-authors trace one stubborn lineage of the gut pathogen Clostridioides difficile across Chinese hospitals. The lineage, sequence type 81, makes only one of the two main toxins and resists many antibiotics at the highest rates reported. The team gathered 108 clinical isolates from five major hospitals between 2010 and 2021 and read their whole genomes.
Resistance genes were widespread, and two jumping DNA elements turned up across the set. The genomes were all close cousins, differing by about thirteen core mutations on average. Family-tree analysis split them into two sub-lineages that seem to have emerged on their own. The work maps how this hard-to-treat strain spreads and persists.
Catalog record
| CREATOR | Xufen Xia, Tao Lv, Lisi Zheng, Yuhong Zhao, Ping Shen, Danhua Zhu, Yunbo Chen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |