Excess shed mesothelin disrupts pancreatic cancer cell clustering to impair peritoneal colonization
Theressa Ewa, Neel Panchwagh, Chin‐Hsien Tai, Leela Rani Avula, Sarah Joseph, Michael W. Rudloff, Nargis Malik, Xianyu Zhang, Christine Alewine · 2024
Read Excess shed mesothelin disrupts pancreatic cancer cell clustering to impair peritoneal colonization by Theressa Ewa, Neel Panchwagh, Chin‐Hsien Tai, Leela Rani Avula, Sarah Joseph, Michael W. Rudloff, Nargis Malik, Xianyu Zhang, Christine Alewine (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11646052.txt.
Description
Theressa Ewa and eight co-authors study how a shed protein helps or hinders pancreatic cancer spread within the belly, in a research paper from 2024. The protein, mesothelin, sits on the cancer cell surface but is also cut loose into the fluid around it. Spread to the peritoneum is the second most common pattern in this cancer.
Cells need surface mesothelin gripping a partner protein to cluster together, and clustering drives efficient spread. Flooding the area with the shed form broke up clusters and curbed colonization in mice. Yet the shed form also nudged inflammatory signals that may aid spread by another route. The authors map this double role in detail.
Catalog record
| CREATOR | Theressa Ewa, Neel Panchwagh, Chin‐Hsien Tai, Leela Rani Avula, Sarah Joseph, Michael W. Rudloff, Nargis Malik, Xianyu Zhang, Christine Alewine |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |