Variations on a theme: non-canonical DUF3494 ice-binding proteins
James A Raymond · 2024
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Description
James Raymond catalogs oddball versions of a bacterial ice-binding protein in a 2024 paper. These proteins let microbes grip ice, and one family, built like a barrel of coils, dominates the known types.
Predicted structures reveal many bacterial proteins that twist the family pattern: the opening helix runs far longer, sometimes fourteen coils. Thirteen modeled examples line up water-loving residues at spacings matching the ice lattice. One lab-made version bound ice at trace doses. The variants appear only in bacteria, mostly from icy homes. Most carry a tail motif hinting they are exported from the cell. Raymond reads them as a later branch in the family's evolution.
Catalog record
| CREATOR | James A Raymond |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |