Therapeutic Efficacy of the Inositol D-Pinitol as a Multi-Faceted Disease Modifier in the 5×FAD Humanized Mouse Model of Alzheimer’s Amyloidosis
Dina Medina-Vera, Antonio J López-Gambero, Julia Verheul-Campos, Juan A Navarro, Laura Morelli, Pablo Galeano, Juan Suárez, Carlos Sanjuan, Beatriz Pacheco-Sánchez, Patricia Rivera, Francisco J Pavon-Morón, Cristina Rosell-Valle, Fernando Rodríguez de Fonseca, Rita Businaro · 2024
Read Therapeutic Efficacy of the Inositol D-Pinitol as a Multi-Faceted Disease Modifier in the 5×FAD Humanized Mouse Model of Alzheimer’s Amyloidosis by Dina Medina-Vera, Antonio J López-Gambero, Julia Verheul-Campos, Juan A Navarro, Laura Morelli, Pablo Galeano, Juan Suárez, Carlos Sanjuan, Beatriz Pacheco-Sánchez, Patricia Rivera, Francisco J Pavon-Morón, Cristina Rosell-Valle, Fernando Rodríguez de Fonseca, Rita Businaro (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11644622.txt.
Description
Dina Medina-Vera and co-authors test a plant compound called D-pinitol in a mouse model of Alzheimer disease in work from 2024. The disease involves amyloid deposits, insulin resistance, tau changes, and gut-driven inflammation, and current drugs do not stop it.
Mice with five disease-linked mutations got the compound by mouth daily. Treated mice showed better cognition, lower amyloid and altered tau in the hippocampus, and restored insulin signaling. Hormone levels tied to cognition rose. The compound also protected the gut barrier, lowered bacterial toxin levels, and balanced gut microbes. The authors see it as a candidate disease modifier.
Catalog record
| CREATOR | Dina Medina-Vera, Antonio J López-Gambero, Julia Verheul-Campos, Juan A Navarro, Laura Morelli, Pablo Galeano, Juan Suárez, Carlos Sanjuan, Beatriz Pacheco-Sánchez, Patricia Rivera, Francisco J Pavon-Morón, Cristina Rosell-Valle, Fernando Rodríguez de Fonseca, Rita Businaro |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |