Flavonoids Derived from the Roots of Lespedeza bicolor Inhibit the Activity of SARS-CoV Papain-like Protease
Hyun Sim Woo, Kon Ho Lee, Ki Hun Park, Dae Wook Kim · 2024
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Description
Hyun Sim Woo and co-authors find plant compounds that block a viral enzyme in a 2024 study. The enzyme, a papain like protease, helps the SARS coronavirus copy itself, and no natural small molecule had been reported against it.
Nine flavonoids were isolated from the root bark of a flowering shrub. Most of them slowed the enzyme in step with dose, with potencies spanning a wide range. Comparing the related structures showed which decorations help and which hurt: one oxygen bearing group raised activity, a methyl group lowered it. All the blockers acted by a noncompetitive route, gripping somewhere other than the active site. The shrub's plant family is rich in this compound class.
Catalog record
| CREATOR | Hyun Sim Woo, Kon Ho Lee, Ki Hun Park, Dae Wook Kim |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |