In Vitro and In Silico Evaluation of Syzygium aromaticum Essential Oil: Effects on Mitochondrial Function and Cytotoxic Potential Against Cancer Cells
Andreea Munteanu, Armand Gogulescu, Codruța Șoica, Alexandra Mioc, Marius Mioc, Andreea Milan, Alexandra Teodora Lukinich-Gruia, Maria-Alexandra Pricop, Calin Jianu, Christian Banciu, Roxana Racoviceanu, Lhou Majidi · 2024
Read In Vitro and In Silico Evaluation of Syzygium aromaticum Essential Oil: Effects on Mitochondrial Function and Cytotoxic Potential Against Cancer Cells by Andreea Munteanu, Armand Gogulescu, Codruța Șoica, Alexandra Mioc, Marius Mioc, Andreea Milan, Alexandra Teodora Lukinich-Gruia, Maria-Alexandra Pricop, Calin Jianu, Christian Banciu, Roxana Racoviceanu, Lhou Majidi (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11644429.txt.
Description
Andreea Munteanu and eleven co-authors check clove essential oil against cancer cells in dishes and in computer models, in a two thousand twenty-four pharmacology paper. Clove oil is rich in eugenol, long suspected of anticancer activity.
Steam distillation yielded oil that was three quarters eugenol. Formulations with Tween-20 or PEG-400 carriers killed melanoma, colon, and skin cancer cells most effectively at the tested dose, sparing noncancerous cells comparatively. The oil disrupted mitochondrial respiration and uncoupled energy making, consistent with a rise in reactive oxygen species. Docking model runs nominated the enzyme PI3K alpha and the minor constituent calamenene as a surprisingly strong binder, hinting synergy among the oil's components.
Catalog record
| CREATOR | Andreea Munteanu, Armand Gogulescu, Codruța Șoica, Alexandra Mioc, Marius Mioc, Andreea Milan, Alexandra Teodora Lukinich-Gruia, Maria-Alexandra Pricop, Calin Jianu, Christian Banciu, Roxana Racoviceanu, Lhou Majidi |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |