Bio-Inspired Polymeric Solid Lipid Nanoparticles for siRNA Delivery: Cytotoxicity and Cellular Uptake In Vitro
Keelan Jagaran, Saffiya Habib, Moganavelli Singh · 2024
Read Bio-Inspired Polymeric Solid Lipid Nanoparticles for siRNA Delivery: Cytotoxicity and Cellular Uptake In Vitro by Keelan Jagaran, Saffiya Habib, Moganavelli Singh (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11644305.txt.
Description
Keelan Jagaran, Saffiya Habib, and Moganavelli Singh present a 2024 lab study of fat-based carriers for gene-silencing cargo. Current care for brain diseases such as Parkinson's mostly eases symptoms. A carrier that ferries silencing RNA into cells could treat causes instead. The team built carriers from natural fats, added a ginkgo leaf extract, and coated them so the cargo binds tight.
The coated carriers held the cargo and shielded it from enzymes that chew RNA. In two human cell lines, harm stayed low, under 15 percent. A cell death signal even fell in treated cells. The carriers entered cells well in both lines. The work is a first proof step toward RNA care for brain disease, well short of patient use.
Catalog record
| CREATOR | Keelan Jagaran, Saffiya Habib, Moganavelli Singh |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |