Genetic Risk, BMI Status, BMI Change Patterns, and the Risk of Steatotic Liver Disease and Liver Enzyme Elevation in Chinese Adults
Juan Yang, Chan Tian, Maojie Liu, Haiyan Guo, Fei Lin, Yang Ding, Wentao Yao, Jiahao Zhang, Jingyi Fan, Chengxiao Yu, Jing Lu, Qun Zhang, Luis A Moreno, Aldona Wierzbicka-Rucinska, Zuzanna Goluch · 2024
Read Genetic Risk, BMI Status, BMI Change Patterns, and the Risk of Steatotic Liver Disease and Liver Enzyme Elevation in Chinese Adults by Juan Yang, Chan Tian, Maojie Liu, Haiyan Guo, Fei Lin, Yang Ding, Wentao Yao, Jiahao Zhang, Jingyi Fan, Chengxiao Yu, Jing Lu, Qun Zhang, Luis A Moreno, Aldona Wierzbicka-Rucinska, Zuzanna Goluch (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11644279.txt.
Description
Juan Yang and co-authors asked in 2024 whether losing weight can offset a genetic tilt toward fatty liver disease in Chinese adults. More than ten thousand people joined the snapshot analysis and six thousand the follow-up. Genetic risk was scored from four known gene variants, and weight change patterns were tracked between visits.
Risk rose in steps with both body mass and genetic score. Losing weight cut the risk of fatty liver by about seventy percent versus staying overweight, and liver enzyme risks fell by similar shares. The absolute gains from weight loss ran largest in people with the highest genetic scores. Genes and weight also interacted on enzyme levels. The authors conclude a healthy weight protects everyone, and protects the genetically loaded most.
Catalog record
| CREATOR | Juan Yang, Chan Tian, Maojie Liu, Haiyan Guo, Fei Lin, Yang Ding, Wentao Yao, Jiahao Zhang, Jingyi Fan, Chengxiao Yu, Jing Lu, Qun Zhang, Luis A Moreno, Aldona Wierzbicka-Rucinska, Zuzanna Goluch |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |