Elucidation of the Active Agents in a West African Ground Herbal Medicine Formulation That Elicit Antimalarial Activities in In Vitro and In Vivo Models
Solomon Owumi, John O. Olanlokun, Bocheng Wu, Abiola Marian Duro-Ladipo, Sophia E. Oyelere, Shabana I. Khan, Adegboyega K. Oyelere · 2024
Read Elucidation of the Active Agents in a West African Ground Herbal Medicine Formulation That Elicit Antimalarial Activities in In Vitro and In Vivo Models by Solomon Owumi, John O. Olanlokun, Bocheng Wu, Abiola Marian Duro-Ladipo, Sophia E. Oyelere, Shabana I. Khan, Adegboyega K. Oyelere (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11643963.txt.
Description
Seven researchers hunt the active ingredients in a West African herbal malaria remedy in a paper from 2024. The remedy, Agunmu, is a ground mix of five plants sold in open markets. Locals use it widely against malaria. The team made an alcohol extract and mapped its chemistry with modern instruments. They then tested it on malaria parasites in dishes and in infected mice.
The extract fought both drug-sensitive and drug-resistant parasite strains. Chemical analysis pinned the activity on a flavonoid family, including kaempferol and quercetin. Toxic acids feared from one ingredient were barely present. Treated mice cleared parasites, with liver and spleen checks included. The authors say the work validates parts of the traditional formula.
Catalog record
| CREATOR | Solomon Owumi, John O. Olanlokun, Bocheng Wu, Abiola Marian Duro-Ladipo, Sophia E. Oyelere, Shabana I. Khan, Adegboyega K. Oyelere |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |