Synthesis of Antimicrobial Norlabdane Compounds with Rearranged Cycle B and Molecular Docking Studies
Alexandru Ciocarlan, Lidia Lungu, Sergiu Shova, Nicoleta Vornicu, Natalia Bolocan, Veaceslav Kulcitki, Aculina Aricu, Xun Song · 2024
Read Synthesis of Antimicrobial Norlabdane Compounds with Rearranged Cycle B and Molecular Docking Studies by Alexandru Ciocarlan, Lidia Lungu, Sergiu Shova, Nicoleta Vornicu, Natalia Bolocan, Veaceslav Kulcitki, Aculina Aricu, Xun Song (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11643738.txt.
Description
Alexandru Ciocarlan and co-authors synthesize, in a 2024 paper, new ring-reshaped compounds from a plant-derived starting material and test them against microbes. The team began with sclareolide, a cheap natural product sold commercially, and cut its ring system down into smaller norlabdane shapes. A classic oxidation step opened the way to the rearranged ring. Spectra and crystal structures confirmed each new compound's shape.
Two of the four compounds fought fungi and bacteria as well as or better than standard reference drugs. Computer docking into four microbial enzyme targets matched the lab results and helped explain the strong showing. Energy calculations compared the stability of the two star compounds across solvents. The authors offer the pair as leads for new antimicrobial development, a field hungry for fresh chemical shapes.
Catalog record
| CREATOR | Alexandru Ciocarlan, Lidia Lungu, Sergiu Shova, Nicoleta Vornicu, Natalia Bolocan, Veaceslav Kulcitki, Aculina Aricu, Xun Song |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |