Synthesis, Characterization and Antimicrobial Activity of Trimethylantimony(V) Biscyanoximates, a New Family of Antimicrobials
Seth A Amankrah, Tarosha Salpadoru, Kaitlyn Cotton, Marianna A Patrauchan, Karen L Wozniak, Nikolay Gerasimchuk, Jingang Liu · 2024
Read Synthesis, Characterization and Antimicrobial Activity of Trimethylantimony(V) Biscyanoximates, a New Family of Antimicrobials by Seth A Amankrah, Tarosha Salpadoru, Kaitlyn Cotton, Marianna A Patrauchan, Karen L Wozniak, Nikolay Gerasimchuk, Jingang Liu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11643687.txt.
Description
Seth A Amankrah and co-authors create a second generation of antimony-based antimicrobials and test them against bacteria and fungi. Their 2024 paper responds to rising drug resistance and a thin pipeline of new agents. An earlier family built on a bulky carbon frame already killed several pathogens; this round swaps in a compact trimethyl frame to make the chemistry simpler and more flexible.
Nine new compounds were made in high yield, pairing the antimony core with three chlorine-bearing ligand types known to be active. Structure checks used NMR, infrared spectra, heat analysis, and X-ray crystallography. The team then screened the compounds against three bacterial species. The family offers a fresh scaffold in the search for resistance-proof drugs.
Catalog record
| CREATOR | Seth A Amankrah, Tarosha Salpadoru, Kaitlyn Cotton, Marianna A Patrauchan, Karen L Wozniak, Nikolay Gerasimchuk, Jingang Liu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |