The Role of Vitamin D Deficiency in Hepatic Encephalopathy: A Review of Pathophysiology, Clinical Outcomes, and Therapeutic Potential
Coplen D Johnson, Christopher M Stevens, Matthew R Bennett, Adam B Litch, Eugenie M Rodrigue, Maria D Quintanilla, Eric Wallace, Massoud Allahyari · 2024
Read The Role of Vitamin D Deficiency in Hepatic Encephalopathy: A Review of Pathophysiology, Clinical Outcomes, and Therapeutic Potential by Coplen D Johnson, Christopher M Stevens, Matthew R Bennett, Adam B Litch, Eugenie M Rodrigue, Maria D Quintanilla, Eric Wallace, Massoud Allahyari (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11643663.txt.
Description
Brain fog in liver disease, called hepatic encephalopathy, burdens patients and hospitals alike. Coplen Johnson and co-authors review a suspect hiding in plain sight: vitamin D deficiency, common in scarred livers. They trace how low vitamin D could feed the condition through oxidative stress, ammonia build-up, and failing liver function. They also gather studies tying lower blood levels of the vitamin's storage form to worse grades of the brain disorder.
Trial evidence for giving the vitamin remains thin, though its antioxidant action hints at benefit. The authors call for long-term studies and randomised trials, including in patients receiving a shunt procedure that itself can trigger the brain disorder. Clarifying the vitamin's role could open a cheap lever in managing a costly complication.
Catalog record
| CREATOR | Coplen D Johnson, Christopher M Stevens, Matthew R Bennett, Adam B Litch, Eugenie M Rodrigue, Maria D Quintanilla, Eric Wallace, Massoud Allahyari |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |