Cell-autonomous timing drives the vertebrate segmentation clock’s wave pattern
Laurel A Rohde, Arianne Bercowsky-Rama, Guillaume Valentin, Sundar Ram Naganathan, Ravi A Desai, Petr Strnad, Daniele Soroldoni, Andrew C Oates, Yasumasa Bessho, Laurel A Rohde, Arianne Bercowsky-Rama, Guillaume Valentin, Sundar Ram Naganathan, Ravi A Desai, Petr Strnad, Daniele Soroldoni, Andrew C · 2024
Read Cell-autonomous timing drives the vertebrate segmentation clock’s wave pattern by Laurel A Rohde, Arianne Bercowsky-Rama, Guillaume Valentin, Sundar Ram Naganathan, Ravi A Desai, Petr Strnad, Daniele Soroldoni, Andrew C Oates, Yasumasa Bessho, Laurel A Rohde, Arianne Bercowsky-Rama, Guillaume Valentin, Sundar Ram Naganathan, Ravi A Desai, Petr Strnad, Daniele Soroldoni, Andrew C (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11643631.txt.
Description
As a young vertebrate embryo grows, its body forms segments in a steady rhythm, guided by a genetic clock whose activity sweeps through tissue in waves. Laurel Rohde and co-authors test whether those waves need signals between cells. They grow single cells from the relevant tissue alone and watch their clocks run.
Isolated cells slowed their oscillations and stopped at the right pace, much as cells do inside the embryo. The pattern suggests each cell carries its own timer, started when it leaves the tailbud, and position comes from elapsed time. Adding a growth factor stretched the timer's run. The team concludes the wave pattern is driven from inside cells, with outside signals tuning the timer.
Catalog record
| CREATOR | Laurel A Rohde, Arianne Bercowsky-Rama, Guillaume Valentin, Sundar Ram Naganathan, Ravi A Desai, Petr Strnad, Daniele Soroldoni, Andrew C Oates, Yasumasa Bessho, Laurel A Rohde, Arianne Bercowsky-Rama, Guillaume Valentin, Sundar Ram Naganathan, Ravi A Desai, Petr Strnad, Daniele Soroldoni, Andrew C |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |