Gut Microbiota Modulates Fgf21 Expression and Metabolic Phenotypes Induced by Ketogenic Diet
Xinyi Wei, Yunxu Lu, Shangyu Hong, Jose M Miranda · 2024
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Description
The ketogenic diet, very low in carbohydrates, lowers body weight and blood sugar, but how it does so is not fully known. Xinyi Wei, Yunxu Lu, and Shangyu Hong tested the role of gut microbes in 2024 using mice. When antibiotics wiped out gut microbes, the diet lost much of its effect on weight and glucose, which pointed to the microbes as a needed link.
The chain ran through a hormone called FGF21, made in the liver. Gut microbes changed levels of the amino acid valine in blood, and valine in turn tuned how much FGF21 the liver made. Adding valine back blunted the diet's gains. The work maps a diet-microbe-hormone path that could guide new treatments.
Catalog record
| CREATOR | Xinyi Wei, Yunxu Lu, Shangyu Hong, Jose M Miranda |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |