Glycine-Based [3+2] Cycloaddition for the Synthesis of Pyrrolidine-Containing Polycyclic Compounds
Tieli Zhou, Xiaofeng Zhang, Desheng Zhan, Wei Zhang · 2024
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Description
Ring-shaped nitrogen compounds called pyrrolidines appear in many drug candidates, and chemists want clean ways to build them. Tieli Zhou and co-authors review a route that starts from glycine, a simple amino acid, in a 2024 paper.
The review covers recent work on a joining reaction that pairs glycine-derived pieces with partners to close the five-membered ring. Many groups then add a second ring-closing step in the same pot, yielding complex fused structures in one run. Method design, the range of starting materials, and how the reactions work are all discussed. Uses in drug discovery get a brief look. The authors aim to help chemists plan faster, greener routes to these prized scaffolds.
Catalog record
| CREATOR | Tieli Zhou, Xiaofeng Zhang, Desheng Zhan, Wei Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |