Phytochemical, Cytoprotective Profiling, and Anti-Inflammatory Potential of Colchicum luteum in Rheumatoid Arthritis: An Experimental and Simulation Study
Huda Abbasi, Maria Sharif, Peter John, Attya Bhatti, Muhammad Qasim Hayat, Qaisar Mansoor, Lindsay Brown, Tyler Barker · 2024
Read Phytochemical, Cytoprotective Profiling, and Anti-Inflammatory Potential of Colchicum luteum in Rheumatoid Arthritis: An Experimental and Simulation Study by Huda Abbasi, Maria Sharif, Peter John, Attya Bhatti, Muhammad Qasim Hayat, Qaisar Mansoor, Lindsay Brown, Tyler Barker (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11643434.txt.
Description
Huda Abbasi and co-authors test, in a 2024 study, a plant extract as a gentler option for rheumatoid arthritis. The standard first-line drugs for this joint disease can carry heavy side effects. The plant, Colchicum luteum, was made into an alcohol-water extract and checked in cells, in mice with induced arthritis, and in computer models of two inflammation targets.
The extract showed strong antioxidant and anti-inflammatory action in lab tests and no toxicity in mice even at a very high dose. In arthritic mice it cut paw swelling, joint scores, and a blood inflammation marker more than ibuprofen did, and it turned down the COX-2 and TNF genes. Tissue slides told the same story. Computer work singled out one compound with strong binding to both targets. The authors propose the plant as a safer, multi-target candidate.
Catalog record
| CREATOR | Huda Abbasi, Maria Sharif, Peter John, Attya Bhatti, Muhammad Qasim Hayat, Qaisar Mansoor, Lindsay Brown, Tyler Barker |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |