Simultaneous Down-Regulation of Intracellular MicroRNA-21 and hTERT mRNA Using AS1411-Functionallized Gold Nanoprobes to Achieve Targeted Anti-Tumor Therapy
Qinghong Ji, Qiangqiang Yang, Mengyao Ou, Min Hong, Gregory Guisbiers · 2024
Read Simultaneous Down-Regulation of Intracellular MicroRNA-21 and hTERT mRNA Using AS1411-Functionallized Gold Nanoprobes to Achieve Targeted Anti-Tumor Therapy by Qinghong Ji, Qiangqiang Yang, Mengyao Ou, Min Hong, Gregory Guisbiers (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11643209.txt.
Description
Qinghong Ji and co-authors build a gold nanoparticle probe designed to silence two cancer-driving messages at once inside tumor cells. Most cancers overproduce telomerase, the enzyme that maintains chromosome ends, and its core message is a natural drug target. A small RNA called microRNA-21 indirectly boosts that same enzyme and drives spread. Their probe carries antisense strands against both targets, plus a targeting aptamer that homes to cancer cells.
In cell studies, the probes triggered cancer cell death and slowed growth by cutting the telomerase message. In mice bearing breast tumors, the probes gathered at the tumor and shrank its growth. The authors see promise for targeted therapy hitting two linked drivers simultaneously.
Catalog record
| CREATOR | Qinghong Ji, Qiangqiang Yang, Mengyao Ou, Min Hong, Gregory Guisbiers |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |