Perspectives on Applications of 19F-NMR in Fragment-Based Drug Discovery
Qingxin Li, CongBao Kang, Robert Powers · 2024
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Description
Qingxin Li and co-authors present a 2024 review on a magnetic scanning method that aids drug discovery from small fragments. Fragment-based discovery starts from tiny compounds that bind weakly to a target, then grows them into strong drugs. Many screening tools exist, but one based on fluorine atoms has special strengths.
Fluorine does not occur in natural biological systems, so its signal stands out cleanly against background. That makes the method a sharp way to spot weak binding to targets such as proteins and RNA. The review gathers uses of the method across many targets. The authors argue it will stay a core tool in the search for new drugs.
Catalog record
| CREATOR | Qingxin Li, CongBao Kang, Robert Powers |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |