Pan-cancer analysis of B3GNT5 with potential implications for cancer immunotherapy and cancer stem cell stemness
Feng Peng, Yechen Feng, Shuo Yu, Ruizhi He, Hebin Wang, Yu Xie, Renyi Qin, Zhiwen Luo, Zhiwen Luo, Zhiwen Luo · 2024
Read Pan-cancer analysis of B3GNT5 with potential implications for cancer immunotherapy and cancer stem cell stemness by Feng Peng, Yechen Feng, Shuo Yu, Ruizhi He, Hebin Wang, Yu Xie, Renyi Qin, Zhiwen Luo, Zhiwen Luo, Zhiwen Luo (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11642946.txt.
Description
Feng Peng and co-authors map a sugar-building gene, B3GNT5, across all cancer kinds in two big data banks. The gene helps build milk sugars and fat-linked sugars, and past work tied it to T cell rush-ins at tumors. Their 2024 scan reads its level by tumor kind, next to fate, immune cell counts, and stem-like marks in cancer cells.
The gene ran high or low by kind, with high grades tied to worse fate in much of the set. Its level tracked immune checks, signal goods, and stem marks in step. In dish and mouse tests, a drug-like block of the gene dulled T cell kills of tumor cells. Silencing the gene in pancreas cancer cells cost them ball growth and self-renewal. The team pitches the gene as a joint mark of fate and immune talk.
Catalog record
| CREATOR | Feng Peng, Yechen Feng, Shuo Yu, Ruizhi He, Hebin Wang, Yu Xie, Renyi Qin, Zhiwen Luo, Zhiwen Luo, Zhiwen Luo |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |