New-Generation Antibacterial Agent—Cellulose-Binding Thermostable TP84_Endolysin
Małgorzata Ponikowska, Joanna Żebrowska, Piotr M Skowron, Antonella Piozzi · 2024
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Description
Malgorzata Ponikowska, Joanna Zebrowska, and Piotr Skowron build a heat-stable antibacterial enzyme that sticks to cellulose, in a 2024 paper. The enzyme comes from a bacterial virus and digests the cell walls of its host bacteria. Keeping such enzymes at the site of action is hard because they diffuse away.
The team fused the enzyme to a cellulose-binding part and produced it in lab bacteria. The fusion kept full activity after heating across a wide range and stayed active near its melting point. It attacked several heat-loving bacteria and reduced biofilms. Binding to cellulose could load it onto wound dressings, valves, or food packaging.
Catalog record
| CREATOR | Małgorzata Ponikowska, Joanna Żebrowska, Piotr M Skowron, Antonella Piozzi |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |