Exploring the Relationship Between VMAT2 and DAT Expression, Psychotic Experiences, Craving, and Treatment Motivation in Male Patients with Methamphetamine Use Disorder
Mualla Keskinsezer, Ahmet Bulent Yazici, Gamze Guney Eskiler, Kaan Furkan Hamarat, Onur Davutoglu, Esra Yazici · 2024
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Description
Mualla Keskinsezer and five co-authors measure two dopamine-handling proteins in men with methamphetamine use disorder. Fifty patients and one hundred control men, split into smokers and nonsmokers, gave blood samples and answered clinical questionnaires. The patients scored far higher on scales of unusual psychic experiences and distress. Their blood showed lower levels of the transporter protein VMAT2, in both gene activity and protein amount, than the controls.
The other transporter, DAT, showed a split pattern: gene activity ran higher in patients while protein ran lower. None of the measures tracked craving, treatment motivation, or symptom scores within the patient group. One finding stood out for diagnosis: low VMAT2 gene activity marked the disorder against nonsmoking controls, while high DAT gene activity marked tobacco use instead. The authors present both genes as possible blood markers worth further study.
Catalog record
| CREATOR | Mualla Keskinsezer, Ahmet Bulent Yazici, Gamze Guney Eskiler, Kaan Furkan Hamarat, Onur Davutoglu, Esra Yazici |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |