Vortex-Mixing Microfluidic Fabrication of Micafungin-Loaded Magnetite–Salicylic Acid–Silica Nanocomposite with Sustained-Release Capacity
Doina-Antonia Mercan, Adelina-Gabriela Niculescu, Alexandra Cătălina Bîrcă, Diana-Elena Cristea, Alina Moroșan, Dana-Ionela Tudorache, Bogdan Purcăreanu, Bogdan Ștefan Vasile, Dana Radu, Mihai Alexandru Grigoroscuta, Tony Hadibarata, Dan Eduard Mihaiescu, Alexandru Mihai Grumezescu, Lifeng Yan · 2024
Read Vortex-Mixing Microfluidic Fabrication of Micafungin-Loaded Magnetite–Salicylic Acid–Silica Nanocomposite with Sustained-Release Capacity by Doina-Antonia Mercan, Adelina-Gabriela Niculescu, Alexandra Cătălina Bîrcă, Diana-Elena Cristea, Alina Moroșan, Dana-Ionela Tudorache, Bogdan Purcăreanu, Bogdan Ștefan Vasile, Dana Radu, Mihai Alexandru Grigoroscuta, Tony Hadibarata, Dan Eduard Mihaiescu, Alexandru Mihai Grumezescu, Lifeng Yan (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11642680.txt.
Description
Doina-Antonia Mercan and co-authors build a slow release carrier for an antifungal drug in a 2024 study. The drug, micafungin, fights serious fungal infections and sits on a global priority list, yet dosing it well is hard.
Their carrier starts with tiny iron oxide cores, five to seven nanometers wide, spun in a vortex mixing device. A salicylic acid shell steadies the cores, and a porous silica shell grows over them in a magnetic field. The drug loads into that shell. A battery of imaging and chemical tests confirmed the structure. Flow tests showed a slow release, with about half the drug out after two hours, and a fine mass analysis verified the cargo at the molecular level.
Catalog record
| CREATOR | Doina-Antonia Mercan, Adelina-Gabriela Niculescu, Alexandra Cătălina Bîrcă, Diana-Elena Cristea, Alina Moroșan, Dana-Ionela Tudorache, Bogdan Purcăreanu, Bogdan Ștefan Vasile, Dana Radu, Mihai Alexandru Grigoroscuta, Tony Hadibarata, Dan Eduard Mihaiescu, Alexandru Mihai Grumezescu, Lifeng Yan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |