Secondary Brain Injury After Parenchymal Cerebral Hemorrhage in Humans: The Role of NOX2-Mediated Oxidative Stress and Endothelin-1
Manuela De Michele, Paolo Amisano, Oscar G. Schiavo, Vittoria Cammisotto, Roberto Carnevale, Maurizio Forte, Vittorio Picchio, Antonio Ciacciarelli, Irene Berto, Ugo Angeloni, Silvia Pugliese, Danilo Toni, Svetlana Lorenzano · 2024
Read Secondary Brain Injury After Parenchymal Cerebral Hemorrhage in Humans: The Role of NOX2-Mediated Oxidative Stress and Endothelin-1 by Manuela De Michele, Paolo Amisano, Oscar G. Schiavo, Vittoria Cammisotto, Roberto Carnevale, Maurizio Forte, Vittorio Picchio, Antonio Ciacciarelli, Irene Berto, Ugo Angeloni, Silvia Pugliese, Danilo Toni, Svetlana Lorenzano (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11642479.txt.
Description
Manuela De Michele and co-authors study secondary injury around a brain bleed in human patients, focusing on oxidative stress and a vessel-tightening substance. After bleeding inside the brain, the tissue around the clot can suffer low blood flow and further ischemic damage, worsening outlook. The team tracked blood markers at three points after onset.
A marker of oxidant enzyme activation was higher at admission in patients who went on to show ischemic lesions around the bleed, and it tracked with worse swelling later. Lesion development also went with larger bleeds and more swelling and shift. The vessel substance showed an opposite link with later bleed size, which the authors tie to its tightening effect on the torn vessel. They propose oxidant activation helps drive the secondary injury.
Catalog record
| CREATOR | Manuela De Michele, Paolo Amisano, Oscar G. Schiavo, Vittoria Cammisotto, Roberto Carnevale, Maurizio Forte, Vittorio Picchio, Antonio Ciacciarelli, Irene Berto, Ugo Angeloni, Silvia Pugliese, Danilo Toni, Svetlana Lorenzano |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |