Modulating Amyloid-β Toxicity: In Vitro Analysis of Aβ42(G37V) Variant Impact on Aβ42 Aggregation and Cytotoxicity
Shu-Hsiang Huang, Shang-Ting Fang, Chin-Hao Yang, Je-Wen Liou, Yi-Cheng Chen, Luigi Casella · 2024
Read Modulating Amyloid-β Toxicity: In Vitro Analysis of Aβ42(G37V) Variant Impact on Aβ42 Aggregation and Cytotoxicity by Shu-Hsiang Huang, Shang-Ting Fang, Chin-Hao Yang, Je-Wen Liou, Yi-Cheng Chen, Luigi Casella (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11642391.txt.
Description
Shu-Hsiang Huang and co-authors study a variant of amyloid-beta in cell experiments reported in 2024. Alzheimer's disease is linked to toxic clumps of amyloid-beta, and the form called Aβ42 plays a central role. The team tested a variant with one amino acid swapped, known as G37V.
Adding the variant sped up clumping of Aβ42 and changed the shape of the clumps that formed. Cells exposed to these clumps survived better than cells exposed to Aβ42 alone. The variant also cut the rise in reactive oxygen species and lipid damage that Aβ42 normally causes. The authors suggest the variant could guide new ways to lower amyloid toxicity.
Catalog record
| CREATOR | Shu-Hsiang Huang, Shang-Ting Fang, Chin-Hao Yang, Je-Wen Liou, Yi-Cheng Chen, Luigi Casella |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |