What Is New in Morphea—Narrative Review on Molecular Aspects and New Targeted Therapies
Tomasz Stein, Paulina Cieplewicz-Guźla, Katarzyna Iżykowska, Monika Pieniawska, Ryszard Żaba, Aleksandra Dańczak-Pazdrowska, Adriana Polańska · 2024
Read What Is New in Morphea—Narrative Review on Molecular Aspects and New Targeted Therapies by Tomasz Stein, Paulina Cieplewicz-Guźla, Katarzyna Iżykowska, Monika Pieniawska, Ryszard Żaba, Aleksandra Dańczak-Pazdrowska, Adriana Polańska (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11642389.txt.
Description
Tomasz Stein and six colleagues review new knowledge about morphea, also called localized scleroderma. In this chronic autoimmune disease, excess collagen hardens patches of skin and the tissue beneath. Its causes remain partly unclear, mixing vessel damage, immune faults, and outside triggers.
The review stresses genes and epigenetics: changes that switch genes on or off without altering the DNA code, such as microRNAs and methylation. It then surveys fresh treatment options drawn from case reports. Drugs discussed include tocilizumab, abatacept, JAK inhibitors such as tofacitinib, and the cancer drug imatinib. The authors map where targeted therapy might fit for patients whom standard care fails.
Catalog record
| CREATOR | Tomasz Stein, Paulina Cieplewicz-Guźla, Katarzyna Iżykowska, Monika Pieniawska, Ryszard Żaba, Aleksandra Dańczak-Pazdrowska, Adriana Polańska |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |