Low Prostaglandin E2 but High Prostaglandin D2, a Paradoxical Dissociation in Arachidonic Acid Metabolism in Aspirin-Exacerbated Airway Disease: Role of Airway Epithelium
César Picado, Liliana Machado-Carvalho, Jordi Roca-Ferrer, Timothy E Albertson · 2024
Read Low Prostaglandin E2 but High Prostaglandin D2, a Paradoxical Dissociation in Arachidonic Acid Metabolism in Aspirin-Exacerbated Airway Disease: Role of Airway Epithelium by César Picado, Liliana Machado-Carvalho, Jordi Roca-Ferrer, Timothy E Albertson (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11642301.txt.
Description
César Picado and three co-authors probe a chemical paradox in aspirin-sensitive airway disease in a 2024 paper. Two sister signals from the same fat pathway split in this disease: one runs low, the other high. Both are made by the same two enzymes, and pain drugs push them in opposite ways as well.
High levels of the second signal track with the nose, lung, and body-wide symptoms aspirin triggers. The authors lay the cause at the airway lining. Cells from patients make less of one enzyme there, which may starve the first signal while the second pours from other cells. The paper builds the case step by step.
Catalog record
| CREATOR | César Picado, Liliana Machado-Carvalho, Jordi Roca-Ferrer, Timothy E Albertson |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |