Peroxisome Proliferator-Activated Receptor Alpha Stimulation Preserves Renal Tight Junction Components in a Rat Model of Early-Stage Diabetic Nephropathy
Lorena Rosas-Martínez, Rafael Rodríguez-Muñoz, María del Carmen Namorado-Tonix, Fanis Missirlis, Leonardo del Valle-Mondragón, Alicia Sánchez-Mendoza, José L Reyes-Sánchez, Luz Graciela Cervantes-Pérez, Maria Kokozidou · 2024
Read Peroxisome Proliferator-Activated Receptor Alpha Stimulation Preserves Renal Tight Junction Components in a Rat Model of Early-Stage Diabetic Nephropathy by Lorena Rosas-Martínez, Rafael Rodríguez-Muñoz, María del Carmen Namorado-Tonix, Fanis Missirlis, Leonardo del Valle-Mondragón, Alicia Sánchez-Mendoza, José L Reyes-Sánchez, Luz Graciela Cervantes-Pérez, Maria Kokozidou (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641852.txt.
Description
Lorena Rosas-Martínez and co-authors test whether a fat-sensing receptor's activation protects the diabetic kidney's seals, in a study published in 2024. Kidney filters and tubules are sealed by tight junction proteins called claudins, which diabetes erodes through oxidative stress and tissue-chewing enzymes. The team used rats with type 2 diabetes that developed early kidney disease by fourteen weeks.
Diabetic rats showed protein in the urine and rising oxidative stress, with claudin-2 and claudin-5 under pressure. Activating the PPAR-alpha receptor lowered blood glucose and restored claudin levels in the glomeruli, proximal tubules, and the loop of Henle. Kidney function improved while the destructive enzymes MMP-2 and MMP-9 quieted. Early treatment aimed at these seals might slow diabetic kidney disease.
Catalog record
| CREATOR | Lorena Rosas-Martínez, Rafael Rodríguez-Muñoz, María del Carmen Namorado-Tonix, Fanis Missirlis, Leonardo del Valle-Mondragón, Alicia Sánchez-Mendoza, José L Reyes-Sánchez, Luz Graciela Cervantes-Pérez, Maria Kokozidou |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |