Circadian Rhythms of Clock Genes After Transplantation of Mesenchymal Stem Cells with Type 2 Diabetes Mellitus
Michiko Horiguchi, Kenichi Yoshihara, Kenji Watanabe, Yuya Tsurudome, Yoichi Mizukami, Kentaro Ushijima · 2024
Read Circadian Rhythms of Clock Genes After Transplantation of Mesenchymal Stem Cells with Type 2 Diabetes Mellitus by Michiko Horiguchi, Kenichi Yoshihara, Kenji Watanabe, Yuya Tsurudome, Yoichi Mizukami, Kentaro Ushijima (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641841.txt.
Description
Michiko Horiguchi and co-authors check whether the daily body clock survives in stem cells taken from a patient with type 2 diabetes. Their 2024 study transplants fat-derived stem cells from a healthy donor and from a diabetic patient, then tracks four clock genes across the day. Stem cell therapy is a hopeful route for diabetes, but a broken clock in the graft could disturb the tissue it joins.
The clock genes rose and fell in near-identical rhythm in both cell groups, in step with the host body. Gene-wide reads then sorted which other genes differed between the diabetic and healthy cells. The reassuring clock result supports the use of a patient's own cells in therapy.
Catalog record
| CREATOR | Michiko Horiguchi, Kenichi Yoshihara, Kenji Watanabe, Yuya Tsurudome, Yoichi Mizukami, Kentaro Ushijima |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 19 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |