One Change, Many Benefits: A Glycine-Modified Bacteriochlorin with NIR Absorption and a Type I Photochemical Mechanism for Versatile Photodynamic Therapy
Mateusz Werłos, Agata Barzowska-Gogola, Barbara Pucelik, Paweł Repetowski, Marta Warszyńska, Janusz M Dąbrowski, Young-Il Jeong · 2024
Read One Change, Many Benefits: A Glycine-Modified Bacteriochlorin with NIR Absorption and a Type I Photochemical Mechanism for Versatile Photodynamic Therapy by Mateusz Werłos, Agata Barzowska-Gogola, Barbara Pucelik, Paweł Repetowski, Marta Warszyńska, Janusz M Dąbrowski, Young-Il Jeong (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641832.txt.
Description
Mateusz Werłos and six co-authors tested a modified light-sensitive dye for cancer therapy that uses light to kill tumors, in a paper from twenty twenty-four. Adding a simple amino acid unit to the dye was the single change under study. The base dye family absorbs deep-red light, which can reach further into tissue.
The modified dye absorbs even deeper-red light and stays stable enough to work. Under light it makes both of the reactive oxygen forms that damage cancer cells. The added units also help it enter a breast cancer cell line that often pumps drugs out. In animal tests, it gathered in tumor vessels before light treatment. The authors see it as a strong candidate for targeted therapy.
Catalog record
| CREATOR | Mateusz Werłos, Agata Barzowska-Gogola, Barbara Pucelik, Paweł Repetowski, Marta Warszyńska, Janusz M Dąbrowski, Young-Il Jeong |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |