Targeting Age-Related Impaired Bone Healing: ZnO Nanoparticle-Infused Composite Fibers Modulate Excessive NETosis and Prolonged Inflammation in Aging
Do-Yeun Kim, Jeong-Hyun Ryu, Jae-Hyung Kim, Eun-Hye Lee, Jeong-Hwa Baek, Kyung Mi Woo · 2024
Read Targeting Age-Related Impaired Bone Healing: ZnO Nanoparticle-Infused Composite Fibers Modulate Excessive NETosis and Prolonged Inflammation in Aging by Do-Yeun Kim, Jeong-Hyun Ryu, Jae-Hyung Kim, Eun-Hye Lee, Jeong-Hwa Baek, Kyung Mi Woo (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641807.txt.
Description
Kim and co-authors ask why old bones heal slowly, and test zinc as part of the answer. In aged mice with skull defects, healing lags, inflammation drags on, and neutrophils overproduce NETs, the web-like traps the cells cast out. Gene sequencing points to disturbed zinc transport, and old neutrophils indeed carry little zinc inside.
The team spins fibers laced with zinc oxide nanoparticles and lays them into the defect. The fibers deliver zinc to the neutrophils, calm the excessive NET release and inflammation, tilt macrophages toward their healing mode, and raise new bone formation. Healing in the aged mice improves markedly. The authors propose zinc-delivering materials as therapy for age-impaired bone repair.
Catalog record
| CREATOR | Do-Yeun Kim, Jeong-Hyun Ryu, Jae-Hyung Kim, Eun-Hye Lee, Jeong-Hwa Baek, Kyung Mi Woo |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |