Macrophage-like Blood Cells Are Involved in Inter-Tissue Communication to Activate JAK/STAT Signaling, Inducing Antitumor Turandot Proteins in Drosophila Fat Body via the TNF-JNK Pathway
Juri Kinoshita, Yuriko Kinoshita, Tadashi Nomura, Yoshihiro H. Inoue · 2024
Read Macrophage-like Blood Cells Are Involved in Inter-Tissue Communication to Activate JAK/STAT Signaling, Inducing Antitumor Turandot Proteins in Drosophila Fat Body via the TNF-JNK Pathway by Juri Kinoshita, Yuriko Kinoshita, Tadashi Nomura, Yoshihiro H. Inoue (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641801.txt.
Description
Juri Kinoshita and co-authors trace how blood cells help fight tumors in fruit flies in this 2024 study. Turandot proteins, made in the fat body, can suppress lymph gland tumors in mutant fly larvae. The authors asked how a tumor signal reaches the fat body.
Normal blood cells moved into mutant larvae went to the tumor and the fat body. There they made a signal that switches on the JAK/STAT pathway. A tumor factor called Eiger drove this through the JNK pathway in the blood cells. Blocking that pathway cut Turandot levels and let tumors grow more. Blood cells thus carry the alarm between tissues.
Catalog record
| CREATOR | Juri Kinoshita, Yuriko Kinoshita, Tadashi Nomura, Yoshihiro H. Inoue |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |