Investigation of Gallium(III) Complexes with Thiouracil Derivatives: Effects of pH on Coordination and Stability
Monika Skrobanska, Michał Zabiszak, Anita M. Grześkiewicz, Malgorzata T. Kaczmarek, Renata Jastrzab · 2024
Read Investigation of Gallium(III) Complexes with Thiouracil Derivatives: Effects of pH on Coordination and Stability by Monika Skrobanska, Michał Zabiszak, Anita M. Grześkiewicz, Malgorzata T. Kaczmarek, Renata Jastrzab (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641691.txt.
Description
Gallium compounds are candidates for future antibacterial and anticancer drugs, but their chemistry in water must be mapped first. Monika Skrobanska and four co-authors studied new gallium complexes with a family of sulfur-bearing compounds called thiouracils, in 2024.
Working in dilute water solutions, the team formed soluble complexes with five related ligands, described here for the first time. Titration plus light-based methods showed which forms appear at each acidity level and how stable each one is. As the water grew less acidic, nitrogen, sulfur, and oxygen atoms all joined in holding the metal. The authors also pinned down one ligand's structure, and they suggest tests under body-like conditions as the next step.
Catalog record
| CREATOR | Monika Skrobanska, Michał Zabiszak, Anita M. Grześkiewicz, Malgorzata T. Kaczmarek, Renata Jastrzab |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |