Study of Host-Guest Interaction and In Vitro Neuroprotective Potential of Cinnamic Acid/Randomly Methylated β-Cyclodextrin Inclusion Complex
Federica De Gaetano, Loredana Leggio, Consuelo Celesti, Fabio Genovese, Marco Falcone, Salvatore Vincenzo Giofrè, Nunzio Iraci, Nunzio Iraci, Cinzia Anna Ventura, Miguel A Esteso, Carmen M Romero · 2024
Read Study of Host-Guest Interaction and In Vitro Neuroprotective Potential of Cinnamic Acid/Randomly Methylated β-Cyclodextrin Inclusion Complex by Federica De Gaetano, Loredana Leggio, Consuelo Celesti, Fabio Genovese, Marco Falcone, Salvatore Vincenzo Giofrè, Nunzio Iraci, Nunzio Iraci, Cinzia Anna Ventura, Miguel A Esteso, Carmen M Romero (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641672.txt.
Description
Federica De Gaetano and co-authors tackle a solubility problem for cinnamic acid, a plant compound with many health effects. The acid barely dissolves in water, so the body absorbs it poorly. Their 2024 study pairs it with a ring-shaped carrier sugar, called RAMEB, that can hold the acid inside its hollow center.
Tests in liquid and solid form showed the pair locks together one-to-one with a strong bond. The paired form dissolves about 250 times better than the acid alone, and within five minutes. Computer models showed the acid's ring end tucked inside the carrier. In cell tests, the pair also shielded nerve-like cells from a toxin.
Catalog record
| CREATOR | Federica De Gaetano, Loredana Leggio, Consuelo Celesti, Fabio Genovese, Marco Falcone, Salvatore Vincenzo Giofrè, Nunzio Iraci, Nunzio Iraci, Cinzia Anna Ventura, Miguel A Esteso, Carmen M Romero |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |