St. John’s Wort Extract Ze 117 and Escitalopram Alter Plasma and Hippocampal Lipidome in a Rat Model of Chronic-Stress-Induced Depression
Hendrik Bussmann, Swen Bremer, Anne Marie Hernier, Jürgen Drewe, Hanns Häberlein, Sebastian Franken, Virginie Freytag, Georg Boonen, Veronika Butterweck, Elena Vianello · 2024
Read St. John’s Wort Extract Ze 117 and Escitalopram Alter Plasma and Hippocampal Lipidome in a Rat Model of Chronic-Stress-Induced Depression by Hendrik Bussmann, Swen Bremer, Anne Marie Hernier, Jürgen Drewe, Hanns Häberlein, Sebastian Franken, Virginie Freytag, Georg Boonen, Veronika Butterweck, Elena Vianello (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641671.txt.
Description
Bussmann and co-authors test in 2024 how a St John's Wort extract and a standard antidepressant change fat profiles in blood and brain in stressed rats. Long stress can spark depression by overdriving a hormone axis, which floods the body with stress steroids. Those steroids can warp brain fat balance and growth.
Rats got stress hormone shots for twenty two days, with one of the two treatments alongside. A swim test scored despair like behavior. Stress cut the time before rats first gave up in the water. The plant extract lengthened that time at some doses. Fat maps of blood and a memory zone were drawn for each group.
Catalog record
| CREATOR | Hendrik Bussmann, Swen Bremer, Anne Marie Hernier, Jürgen Drewe, Hanns Häberlein, Sebastian Franken, Virginie Freytag, Georg Boonen, Veronika Butterweck, Elena Vianello |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |