Ubiquitin-Activating Enzyme E1 (UBA1) as a Prognostic Biomarker and Therapeutic Target in Breast Cancer: Insights into Immune Infiltration and Functional Implications
Mingtao Feng, Huanhuan Cui, Sen Li, Liangdong Li, Changshuai Zhou, Lei Chen, Yiqun Cao, Yang Gao, Deheng Li, Elena Bonanno · 2024
Read Ubiquitin-Activating Enzyme E1 (UBA1) as a Prognostic Biomarker and Therapeutic Target in Breast Cancer: Insights into Immune Infiltration and Functional Implications by Mingtao Feng, Huanhuan Cui, Sen Li, Liangdong Li, Changshuai Zhou, Lei Chen, Yiqun Cao, Yang Gao, Deheng Li, Elena Bonanno (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641640.txt.
Description
Feng and co-authors study in 2024 a cell enzyme called UBA1 as a marker and drug target in breast cancer. The enzyme starts the cell's waste tagging chain, which cancer cells lean on heavily. Its role in breast cancer had been poorly charted, so the team mined patient gene data and ran lab checks.
The gene ran higher in tumor tissue than in healthy tissue. High levels tracked with shorter survival across several measures. The gene also sat in pathways tied to swelling and immune activity, and its level linked to how many immune cells entered tumors. The authors frame it as a sign and a target.
Catalog record
| CREATOR | Mingtao Feng, Huanhuan Cui, Sen Li, Liangdong Li, Changshuai Zhou, Lei Chen, Yiqun Cao, Yang Gao, Deheng Li, Elena Bonanno |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |