PTH1R Suppressed Apoptosis of Mesenchymal Progenitors in Mandibular Growth
Chen Cui, Chuang Lu, Yanling Cai, Yuhua Xiong, Yihong Duan, Kaiwen Lan, Yi Fan, Xuedong Zhou, Xi Wei, Sang-Bae Han · 2024
Read PTH1R Suppressed Apoptosis of Mesenchymal Progenitors in Mandibular Growth by Chen Cui, Chuang Lu, Yanling Cai, Yuhua Xiong, Yihong Duan, Kaiwen Lan, Yi Fan, Xuedong Zhou, Xi Wei, Sang-Bae Han (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641607.txt.
Description
Chen Cui and co-authors study a hormone receptor in 2024 that helps the lower jaw grow in mice. Faults in this receptor cause major bone and tooth defects in the face, and the receptor is known to guide bone-forming cells. Whether it also keeps those young cells alive was less clear, so the team removed the receptor from one cell group.
Mice without the receptor had less jaw bone, in part because more young cells died. Cell tests showed the receptor guards the cell's power units by holding down a calcium channel protein. Forcing that protein high copied the defect, while silencing it rescued the cells. The work links cell survival to jaw growth.
Catalog record
| CREATOR | Chen Cui, Chuang Lu, Yanling Cai, Yuhua Xiong, Yihong Duan, Kaiwen Lan, Yi Fan, Xuedong Zhou, Xi Wei, Sang-Bae Han |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |