Transcriptional Activity of Tumor Necrosis Factor Alpha Genes and Their Receptors in Patients with Varying Degrees of Coronary Artery Disease
Katarzyna Potyka, Józefa Dąbek, Michishige Terasaki · 2024
Read Transcriptional Activity of Tumor Necrosis Factor Alpha Genes and Their Receptors in Patients with Varying Degrees of Coronary Artery Disease by Katarzyna Potyka, Józefa Dąbek, Michishige Terasaki (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641606.txt.
Description
Katarzyna Potyka and Józefa Dąbek track an inflammation signal across the stages of coronary artery disease. The signal is tumor necrosis factor alpha, a protein that helps drive vessel damage. The team measured how actively its gene and its two receptor genes were read in blood cells from 240 people: healthy controls and patients with early, stable, and acute disease.
As the disease stage worsened, the main gene's activity rose significantly, while the receptor genes' activity fell. Neither the number of blocked arteries nor the heart's pumping fraction changed that pattern. The authors read the opposing drift as a fingerprint of the disease's advance. They suggest it could serve as a marker for early, noninvasive diagnosis, catching artery disease before it declares itself in a crisis.
Catalog record
| CREATOR | Katarzyna Potyka, Józefa Dąbek, Michishige Terasaki |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |