Antimicrobial Peptide CATH-2 Attenuates Avian Pathogenic E. coli-Induced Inflammatory Response via NF-κB/NLRP3/MAPK Pathway and Lysosomal Dysfunction in Macrophages
Yating Xu, Liuyi Xu, Tingting Zhang, Hongliang Tian, Yi Lu, Sha Jiang, Xuefeng Cao, Zhiwei Li, Xiaoxiang Hu, Rendong Fang, Lianci Peng, Tecla Ciociola · 2024
Read Antimicrobial Peptide CATH-2 Attenuates Avian Pathogenic E. coli-Induced Inflammatory Response via NF-κB/NLRP3/MAPK Pathway and Lysosomal Dysfunction in Macrophages by Yating Xu, Liuyi Xu, Tingting Zhang, Hongliang Tian, Yi Lu, Sha Jiang, Xuefeng Cao, Zhiwei Li, Xiaoxiang Hu, Rendong Fang, Lianci Peng, Tecla Ciociola (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641483.txt.
Description
Yating Xu and co-authors show how a chicken immune peptide calms gut inflammation set off by a poultry pathogen. Avian pathogenic Escherichia coli drives costly disease in flocks, partly by over-firing macrophage alarm systems. The peptide CATH-2, a cathelicidin, had hinted at anti-inflammatory power. Working with mouse macrophages infected in dishes, the team traced its action.
Pre-treated cells poured out far less IL-1β, IL-6, and other inflammatory signals. The peptide blocked assembly of the NLRP3 inflammasome and damped the NF-κB and MAPK alarm pathways upstream. It also soured the lysosomes, the cell's recycling bins, and forcing those bins back to acid undid its protection. The chain ties lysosome trouble to the peptide's calming hand, a lead for farm animal medicine.
Catalog record
| CREATOR | Yating Xu, Liuyi Xu, Tingting Zhang, Hongliang Tian, Yi Lu, Sha Jiang, Xuefeng Cao, Zhiwei Li, Xiaoxiang Hu, Rendong Fang, Lianci Peng, Tecla Ciociola |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |