Potential Drug Synergy Through the ERBB2 Pathway in HER2+ Breast Tumors
Yareli Rojas-Salazar, Emiliano Gómez-Montañez, Jorge Rojas-Salazar, Guillermo de Anda-Jáuregui, Enrique Hernández-Lemus · 2024
Read Potential Drug Synergy Through the ERBB2 Pathway in HER2+ Breast Tumors by Yareli Rojas-Salazar, Emiliano Gómez-Montañez, Jorge Rojas-Salazar, Guillermo de Anda-Jáuregui, Enrique Hernández-Lemus (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641395.txt.
Description
Yareli Rojas-Salazar and co-authors hunt in 2024 for drug pairs that may work in synergy against HER2-positive breast tumors. Such tumors overgrow a gene that drives fast spread and poor outlook. Single drugs against that path often fade as resistance builds.
Gene co-expression networks reveal twenty three metabolic paths with strong gene cross-links. Maps for single drugs show their reach across the path and its neighbors. Pair maps, such as two antibody and pill combos, expose joint reach that may lift effect. The network view offers a cheap screen for pairs worth lab testing.
Catalog record
| CREATOR | Yareli Rojas-Salazar, Emiliano Gómez-Montañez, Jorge Rojas-Salazar, Guillermo de Anda-Jáuregui, Enrique Hernández-Lemus |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |