Morphometric Similarity Patterning of Amyloid-β and Tau Proteins Correlates with Transcriptomics in the Alzheimer’s Disease Continuum
Lorenza Brusini, Giorgio Dolci, Lorenzo Pini, Federica Cruciani, Fabrizio Pizzagalli, Paolo Provero, Gloria Menegaz, Ilaria Boscolo Galazzo, Sumonto Mitra · 2024
Read Morphometric Similarity Patterning of Amyloid-β and Tau Proteins Correlates with Transcriptomics in the Alzheimer’s Disease Continuum by Lorenza Brusini, Giorgio Dolci, Lorenzo Pini, Federica Cruciani, Fabrizio Pizzagalli, Paolo Provero, Gloria Menegaz, Ilaria Boscolo Galazzo, Sumonto Mitra (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641379.txt.
Description
Lorenza Brusini and colleagues link patterns of cortical shape change in Alzheimer's disease to gene expression. The disease builds up amyloid-beta and tau proteins in set parts of the brain, but how that links to cortical remodeling was not clear. The team built networks of morphometric similarity, mapping how alike brain region shapes are, in over a hundred amyloid- and tau-positive subjects and a larger negative group.
With gene data from the Allen Human Brain Atlas, the team matched gaps in regional similarity with gene expression. The gene tied most strongly to the changes was BCHE, linked to amyloid balance. Enriched terms flagged the immune response as a key process. The cell types named were astrocytes, microglia, and oligodendrocyte precursors, the brain's support and immune cells.
Catalog record
| CREATOR | Lorenza Brusini, Giorgio Dolci, Lorenzo Pini, Federica Cruciani, Fabrizio Pizzagalli, Paolo Provero, Gloria Menegaz, Ilaria Boscolo Galazzo, Sumonto Mitra |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |