The GPR39 Receptor Plays an Important Role in the Pathogenesis of Overactive Bladder and Corticosterone-Induced Depression
Jan Wróbel, Paulina Iwaniak, Piotr Dobrowolski, Mirosława Chwil, Ilona Sadok, Tomasz Kluz, Artur Wdowiak, Iwona Bojar, Ewa Poleszak, Marcin Misiek, Łukasz Zapała, Ewa M Urbańska, Andrzej Wróbel, Yung-Shun Juan, Wei-Chia Lee · 2024
Read The GPR39 Receptor Plays an Important Role in the Pathogenesis of Overactive Bladder and Corticosterone-Induced Depression by Jan Wróbel, Paulina Iwaniak, Piotr Dobrowolski, Mirosława Chwil, Ilona Sadok, Tomasz Kluz, Artur Wdowiak, Iwona Bojar, Ewa Poleszak, Marcin Misiek, Łukasz Zapała, Ewa M Urbańska, Andrzej Wróbel, Yung-Shun Juan, Wei-Chia Lee (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641341.txt.
Description
Jan Wróbel and co-authors wrote a rat study from 2024 on a receptor that may link depression and overactive bladder, two conditions that often arrive together. Which one causes the other is unclear. The team gave female rats a stress hormone for two weeks, which produced both gloomy behavior and bladder overactivity. They then tested a drug that switches on the GPR39 receptor, hoping it would ease both sets of signs.
The hormone did as expected: the rats gave up sooner in a swim test, bladder readings shifted, brain nourishment factors fell, and inflammation markers rose. The receptor drug reversed the pattern. Behavior and bladder measures eased back toward normal, and blood, bladder, and brain markers followed. The drug also raised a brain-protective acid. The team proposes GPR39 as a drug target for bladder trouble that travels with depression.
Catalog record
| CREATOR | Jan Wróbel, Paulina Iwaniak, Piotr Dobrowolski, Mirosława Chwil, Ilona Sadok, Tomasz Kluz, Artur Wdowiak, Iwona Bojar, Ewa Poleszak, Marcin Misiek, Łukasz Zapała, Ewa M Urbańska, Andrzej Wróbel, Yung-Shun Juan, Wei-Chia Lee |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |