Pleiotropic Associations with Alzheimer’s Disease and Physical Activity: Sex Differences and the Effects of Environment
Yury Loika, Elena Loiko, Irina Culminskaya, Alexander M Kulminski, Hongjun (Harry) Fu · 2024
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Description
Yury Loika and co-authors published this 2024 gene study on Alzheimer's disease and physical activity. Being active may lower the risk of the disease, but genes can push both traits at once. The team hunted for gene spots tied to both, a pattern called pleiotropy. They also asked whether the pattern differs by sex or by country.
The main scan covered about fourteen thousand older US adults of European ancestry. A UK sample of more than two hundred thousand served as a contrast. The team found sixty spots with joint links to disease and activity. Most showed opposed effects, where a variant raised one trait and lowered the other. Few of the links repeated in the UK data, hinting that surroundings matter a lot.
Catalog record
| CREATOR | Yury Loika, Elena Loiko, Irina Culminskaya, Alexander M Kulminski, Hongjun (Harry) Fu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |