Gliotic Response and Reprogramming Potential of Human Müller Cell Line MIO-M1 Exposed to High Glucose and Glucose Fluctuations †
Benedetta Russo, Giorgia D’Addato, Giulia Salvatore, Marika Menduni, Simona Frontoni, Luigi Carbone, Antonella Camaioni, Francesca Gioia Klinger, Massimo De Felici, Fabiana Picconi, Gina La Sala, Toshiyuki Oshitari · 2024
Read Gliotic Response and Reprogramming Potential of Human Müller Cell Line MIO-M1 Exposed to High Glucose and Glucose Fluctuations † by Benedetta Russo, Giorgia D’Addato, Giulia Salvatore, Marika Menduni, Simona Frontoni, Luigi Carbone, Antonella Camaioni, Francesca Gioia Klinger, Massimo De Felici, Fabiana Picconi, Gina La Sala, Toshiyuki Oshitari (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641291.txt.
Description
Benedetta Russo and co-authors study how a human retinal support cell line reacts to high sugar. Their 2024 paper models diabetic eye disease, where early nerve damage in the retina is tied to Müller glia, cells that keep the retina stable and fed. In lower animals, these cells can regrow a damaged retina, a power that fades in humans.
Cells were grown at normal or high sugar, then given steady high sugar or swings in sugar. Cells raised at normal sugar reacted with a stress response and switched on genes tied to reprogramming. Cells raised at high sugar showed raised stress marks but a blunted, adapted response. The contrast hints that long sugar exposure dulls the very response that might aid repair.
Catalog record
| CREATOR | Benedetta Russo, Giorgia D’Addato, Giulia Salvatore, Marika Menduni, Simona Frontoni, Luigi Carbone, Antonella Camaioni, Francesca Gioia Klinger, Massimo De Felici, Fabiana Picconi, Gina La Sala, Toshiyuki Oshitari |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |