Role of Myeloid Cell-Specific Adenylyl Cyclase Type 7 in Lipopolysaccharide- and Alcohol-Induced Immune Responses
Yawen Hu, Sonika Patial, Yogesh Saini, Masami Yoshimura, Babak Baban, Maria Pascual · 2024
Read Role of Myeloid Cell-Specific Adenylyl Cyclase Type 7 in Lipopolysaccharide- and Alcohol-Induced Immune Responses by Yawen Hu, Sonika Patial, Yogesh Saini, Masami Yoshimura, Babak Baban, Maria Pascual (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641285.txt.
Description
Alcohol dulls immune defenses, and one enzyme that makes the messenger cyclic AMP may sit at the crossroads. The authors of a 2024 study focus on adenylyl cyclase type 7, which immune cells carry in strength and which reacts strongly to alcohol. They breed mice whose myeloid immune cells lack the enzyme, then challenge them with a bacterial toxin under different drinking regimes. Survival and cytokine messages in lung and liver are the readouts.
Mice without the enzyme died more often after the toxin challenge. Oddly, long-term drinking rescued them from that fate. Short and long drinking shifted several cytokine messages, sometimes interacting with the missing enzyme. The authors conclude the enzyme helps steer alcohol's effect on innate immunity.
Catalog record
| CREATOR | Yawen Hu, Sonika Patial, Yogesh Saini, Masami Yoshimura, Babak Baban, Maria Pascual |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |