Drosophila: An Important Model for Exploring the Pathways of Inflammatory Bowel Disease (IBD) in the Intestinal Tract
Chuisheng Zeng, Fengying Liu, Yuhan Huang, Qianqian Liang, Xiaohong He, Lingzhi Li, Yongfang Xie · 2024
Read Drosophila: An Important Model for Exploring the Pathways of Inflammatory Bowel Disease (IBD) in the Intestinal Tract by Chuisheng Zeng, Fengying Liu, Yuhan Huang, Qianqian Liang, Xiaohong He, Lingzhi Li, Yongfang Xie (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641265.txt.
Description
The fruit fly seems an unlikely stand-in for the human gut. Chuisheng Zeng and co-authors argue it earns the role for inflammatory bowel disease research. Flies breed fast, live briefly, and share core signaling pathways with mammals. Their gut architecture and immune responses map onto ours in useful ways. The review compares the fly intestine with the mammalian one, pathway by pathway.
Natural products tested across fly and other models get a full hearing. The authors explain how each pathway drives intestinal inflammation in the fly system. They present the fly as a cheap first screen for mechanisms and remedies. Findings then move to costlier models for confirmation.
Catalog record
| CREATOR | Chuisheng Zeng, Fengying Liu, Yuhan Huang, Qianqian Liang, Xiaohong He, Lingzhi Li, Yongfang Xie |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |